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   ​​SCIENTIFIC DRUG-FREE PREVENTION AND TREATMENT OF  DISEASES

A Non-Profit Medical Research Organization  with international scientists
from many countries working to serve humanity
- 501 (c) (3) Pending - 

www. apri-us.orgple text.

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A Special Development by APRI  

ALZHEIMER'S DISEASES

WithPHYTOMEDICINE

THIS IS  PIONEER EXPERIMENTAL PHYTO TREATMENT OF AMYLOID BETA CELLS AND CELL MUTATIONS 
TO PREVENT THE BUILT-UP OF PLAQUE IN THE BRAIN LEADING TO ALZHEIMER'S DISEASE 

dEVELOPMENT TEAM

Science Director:

Medical Director:

Researchers:




Research Coordinator:
BRONSON BAO TRAN, Ph D

Biomedicine and Phytomedicine

the PREVENTIVE TREATMENT of 

OVERVIEW

Alzheimer's Disease is a most damaging neuro degenerative disease affecting over HALF MILLION in the US with 2.7 millions must subsist in mental, emotional and interpersonal miseries each day until they no longer know what life is or where they are... The drug industry has developed hundreds of formula claiming to reduce AD. To date, NO DRUGS can treat AD. Another new battle AD patients: The increased drug costs and drastic cut of Medicaid and Medicare will dampen the hope of many AD patients...while Mesenchymal stem cells (MSCs) research in inflammation and  neuronal regeneration cannot be confirmed for another 10 years. With our current experience in treating PARKINSON'S with bio and phytomedicine, we are hopeful that PHYTOMEDICINE can work on ALZHEIMER'S .

Knowing the etiology and biology of AD, realistically,  EARLY PREVENTION OF ALZHEIMER'S  is the only SENSIBLE OPTION. Early prevention will seek to  minimize degenerated brain cells by strengthen brain’s immune cells, particularly microglia and to stop the buildups of plaques and neurotransmitter network. From knowing how to clear plaque in arteries to treat heart disease, clearing toxic AMYLOID BETA protein plaques with PHYTO-derived amino acids and protein-like molecules is conceivable. Whether we can do the same for the brain inside the brain? That remains to be tested but this is what we must do and will undertake in our future research.

OUR PREVENTIVE TREATMENT PROCESS
for ALZHEIMER'S DISEASE 

Our treatment objectives are: 
A) TO PREVENT THE DETERIORATION OF IMMUNE AND MICROGLIA CELLS AND B) TO STOP, CLEAR THE PLAQUE  BUILD-UPS OF AMYLOID BETA PROTEINS

The complexity of ALZHEIMER'S imposes challenges and limitations to science. But at least we now know how AD began to form: THE WEAKING OF NEURO IMMUNE CELLS and or THE BUILD-UP or CLUMPING of AMYLOID PLAQUE. The task of plaque-removing bio agents is similar to how to clean cholesterol build-ups in the arteries to treat HEART CONDITIONS. The biggest challenge is that the brain is simply not a simple tube like an artery and of course, it is far more difficult. 

Inefficient brain protective mechanisms or malfunctions that allow 
the accumulation of AMYLOID PLAQUE that cause ALZHEIMER'S

The treatment process in PHYTOMEDICINE is to  identify and remove the causes or causal factors of the disease. The formulation of ingredients and therapeutic actions begin with understanding of the  pathological conditions and then to study the suitable drug-free means to treat. Inside the brain, there are actions or molecules that we cannot just act on our own but to provide suitable support for the brain to generate its own defense as a supersedence may trigger a cell mutation leading to diseases including tumors.

FUNCTIONS

POSSIBLE PREVENTIVE ACTION

FACTORS FOR AD

Supporting the brain’s immune cells— microglia astrocytes - is needed but immune boost drugs such as anti-inflammation compounds and immune modulating drugs can cause OVER-STIMULATION. This is where we differ with modern medicine and prefer more NATURAL neurotropic factors

Detect, fight pathogens, toxins, chemicals, etc. work with MICROGLIA cells to control inflammation

IMMUNE CELL​S DEFENSE

Similarly TARGETED MICROGLIAL ACTIVATION and ASTOCYTES MODULATION thru IMMUNE intervention can lead to unknown risk of over-stimulation. Again pharmacological intervention is risky. We prefer to DEVELOP a DIETARY strategy in additions to 
BDNF (Brain-Derived Neurotropic Factor) to let the brain generate its precise level is SAFE and just as effective

Protect and promote brain health - responsible for SYNAPIC, NEURONAL health​ and control INFLAMMATION and clear AMYLOID PROTEIN PLAQUE

MICROGLIA CELL DEFENSE

BRAIN'S HEALTH is the crucial factor in the PREVENTION of neurodegenerative diseases. We prefer not to use chemically synthesized matters for the brain but will combine smart DIET plan combined with PHYTO ingredients and NANOPARTICLE biotech. This method is much SAFER and NATURAL for the human body compared to interjection with drugs or even hormones due to the high risk as we cannot measure, predict or
reverse the process. 

BRAIN HYGIENE and HEALTH functions: NEOPLASTICITY, ROBUST cell environment, MITOCHONDRIAL functions, Estrogen HORMONAL​ balance, EPIGENETIC adaptation, PATHOGEN removal (Oxidative stress, foreign chemicals, excessive free radicals...)

OVERALL BRAIN HEALTH

Key biotechniques that we will seek to employ or develop
in a Preventive Treatment Process for Alzheimer's

DIETARY STRATEGY REGIMENT

To rebuild the brain bio-physiology and brain's health, A SUPPORTIVE BUT CRAFTED DIET REGIMENT is essential. Even with effective remedy but contradicting diet will slow down the TREATMENT TIMING that we need to remove and restore brain's health

BRAIN-DERIVED NEUROTROPIC FACTOR (BDNF)

We do not use "Deep brain stimulation" for PD or AD based on the premise that the brain is technically INJURED inside. To stimulate an injured organ is not logical. A smart BDNF strategic plan will add more needed effects for MICROGLIA cells

TARGETED PHYTO INGREDIENTS in NANOPARTICLE TECH

Similar to Parkinson's, we will derive specific amino acids and precusor molecules from PLANTS with immune support properties​ and combine them with nano particle technique to help the brain to restore and repair synaptic, neuronal health and neuroplasticity

Strategic Support from other bio systems

Neuro health and functions are collaterally supported by specific improvements in the LIVER, CARDIOVASCULAR, GASTRONINTESTINAL and RENAL system. Specific glands are also essential for the brain. The TOTALITY necessity of this treatment will provide strong support for the brain to fight AD.

The above chart illustrates the conceptual framework of our COMPREHENSIVE PREVENTIVE TREATMENT OF
ALZHEIMER'S in our view based on what we know from the causal process of the disease. With PHYTOMEDICINE, we can formulate actions on MULTIPLE targets at the same time to enhance the therapeutic advantages of each treatment component because bio-active ingredients used are NOT drugs therefore will not incur conflicts and harms to the brain. 

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